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KMID : 0882420150890020259
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Korean Journal of Medicine
2015 Volume.89 No. 2 p.259 ~ p.263
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TNF-α Inhibitor Treatment in an Ankylosing Spondylitis Patient with Secondary Amyloidosis that Manifest with Diarrhea: A Case Report
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Lee Jae-Hyun
Moon Jin-Young
Lee Hyun-Woo
Chang Sung-Hae
Lee Eun-Bong
Song Yeong-Wook
Lee Eun-Young
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Abstract
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Secondary amyloidosis (Amyloid A amyloidosis) occurs when serum amyloid S accumulates in various tissues and organs. It often accompanies chronic inflammatory disease, especially rheumatoid arthritis, as well as ankylosing spondylitis (AS) and Crohn’s disease. Although amyloid deposits were reported in 7% of the abdominal fatty tissue samples from AS patients, most of the patients had no symptoms. In a large study, 1.1% of 730 patients with AS were diagnosed with amyloidosis. Most of them showed renal involvement, while none had gastrointestinal symptoms. In South Korea, only a few cases of gastrointestinal involvement of secondary amyloidosis have been reported in AS patients, and there is no report on the effect of a tumor necrosis factor (TNF)-α inhibitor. We report a case of secondary amyloidosis in an AS patient who improved with the TNF-α inhibitor etanercept.
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KEYWORD
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Amyloidosis, Spondylitis, Ankylosing, TNFR-Fc fusion protein
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